Relation between Glucolipid Profile and Small Intestine Histological Patterns in Diabetic Rats Exposed to an Intermittent Dietary Restriction

The effects of an intermittent and prolonged dietary restriction on biochemical variables and histological small intestinal patterns in 12-month-old male eSMT rats are examined. These spontaneously diabetic animals were separated in two groups after weaning: 10 rats fed ad libitum with standard rat chow and 10 rats fed a restricted diet by deprivation of the same food for 24 hours every 72. At 12 months of age, animals were weighed and euthanized after tail vein bleeding for plasma analysis (glycemiaboth fasting and 120 minutes after an oral glucose challenge-, triglyceridemia and total cholesterolemia). Small intestines were removed, weighed and measured in length.